Time-constrained nature-inspired optimization algorithms for an efficient energy management system in smart homes and buildings

This paper proposes two bio-inspired heuristic algorithms, the Moth-Flame Optimization (MFO) algorithm and Genetic Algorithm (GA), for an Energy Management System (EMS) in smart homes and buildings. Their performance in terms of energy cost reduction, minimization of the Peak to Average power Ratio (PAR) and end-user discomfort minimization are analysed and discussed. Then, a hybrid version of GA and MFO, named TG-MFO (Time-constrained Genetic-Moth Flame Optimization), is proposed for achieving the aforementioned objectives. TG-MFO not only hybridizes GA and MFO, but also incorporates time constraints for each appliance to achieve maximum end-user comfort. Different algorithms have been proposed in the literature for energy optimization. However, they have increased end-user frustration in terms of increased waiting time for home appliances to be switched ON. The proposed TG-MFO algorithm is specially designed for nearly-zero end-user discomfort due to scheduling of appliances, keeping in view the timespan of individual appliances. Renewable energy sources and battery storage units are also integrated for achieving maximum end-user benefits. For comparison, five bio-inspired heuristic algorithms, i.e., Genetic Algorithm (GA), Ant Colony Optimization (ACO), Cuckoo Search Algorithm (CSA), Firefly Algorithm (FA) and Moth-Flame Optimization (MFO), are used to achieve the aforementioned objectives in the residential sector in comparison with TG-MFO. The simulations through MATLAB show that our proposed algorithm has reduced the energy cost up to 32.25% for a single user and 49.96% for thirty users in a residential sector compared to unscheduled load

An efficient energy management in office using bio-inspired energy optimization algorithms

Energy is one of the valuable resources in this biosphere. However, with the rapid increase of the population and increasing dependency on the daily use of energy due to smart technologies and the Internet of Things (IoT), the existing resources are becoming scarce. Therefore, to have an optimum usage of the existing energy resources on the consumer side, new techniques and algorithms are being discovered and used in the energy optimization process in the smart grid (SG). In SG, because of the possibility of bi-directional power flow and communication between the utility and consumers, an active and optimized energy scheduling technique is essential, which minimizes the end-user electricity bill, reduces the peak-to-average power ratio (PAR) and reduces the frequency of interruptions. Because of the varying nature of the power consumption patterns of consumers, optimized scheduling of energy consumption is a challenging task. For the maximum benefit of both the utility and consumers, to decide whether to store, buy or sale extra energy, such active environmental features must also be taken into consideration. This paper presents two bio-inspired energy optimization techniques; the grasshopper optimization algorithm (GOA) and bacterial foraging algorithm (BFA), for power scheduling in a single office. It is clear from the simulation results that the consumer electricity bill can be reduced by more than 34.69% and 37.47%, while PAR has a reduction of 56.20% and 20.87% with GOA and BFA scheduling, respectively, as compared to unscheduled energy consumption with the day-ahead pricing (DAP) scheme

Feasibility of a Solar Thermal Power Plant in Pakistan

Pakistan has been facing an unprecedented energy crisis since the last few years. The problem becomes more severe throughout the year. The current energy shortage crisis has badly hit Pakistan’s economy where hundreds of industries have closed due to lack of electricity to fulfil their requirements. The energy supply and demand gap has risen to 5000 MW [1] and is expected to rise considerably in the coming years as shown in Figure 1. Table 1 shows the existing installed power generation in Pakistan. Pakistan has a huge potential in renewable energy especially solar energy to fill this gap if utilized properly. Pakistan, being in the Sun Belt, is ideally located to take advantage of solar energy technologies. This energy source is widely distributed and abundantly available in the country. Pakistan receives 4.45- 5.83 kWh/m2/day of global horizontal insolation as an annual mean value, with 5.30 kWh/m2/day over most areas of the country [2, 3]. This minimum level of solar radiation (4.45 kWh/m2/day) is higher than the world average of 3.61 kWh/m2/day [4] which shows that Pakistan lies in an excellent solar belt range. Pakistan has six main insolation measuring stations, namely Karachi, Islamabad, Lahore, Quetta, Peshawar and Multan and 37 observatories distributed fairly well over the entire country, recording sunshine hours as shown in Table A in Appendix. From the sunshine hours data it can be seen that most of the cities mentioned receive more than 250 sunshine hours a month. 2006 energy policy has resulted in few practical steps taken for utilizing the abundantly available solar resource in Pakistan. A Solar Water Heating System has installed in a Leather Industry for first time in Pakistan. The system, using 400 m2 Evacuated Collector tubes, provides heated water at 70 to 80 oC (at least 10 degree rise to the incoming water) to the already used boiler system, thus saving 33% of the cost. The Project was funded by Higher Education Commission (HEC) under University-Industry Technological Support Program (UITSP). Solar water heating technology is relatively mature technology in Pakistan but its higher capital cost compared to conventional gas heaters has limited its use so far. This technology is widely recommended by a number of public sector organizations in northern mountains where natural gas is limited and difficult. The solar water heaters are now being commercially produced in the private sector. More than 2000 low cost solar cookers are used in Pakistan for cooking purposes. Similarly, solar dryers are used in Gilgit and Skardu (Northern part of Pakistan) to dry large quantities of fruits such as apricot and transport and sell them later in the urban areas, thus bringing economic prosperity to the area. Fresh water unavailability in large parts of Baluchistan, Sind and southern Punjab is a critical issue. Two solar desalination plants consisting of 240 sills each with a capacity of 6000 gallons of seawater/day have been operational at Gawadar in Baluchistan province. A number of such schemes are under active consideration by local governments in Baluchistan and Thar [5]. The need for constructing solar power plants has been realized both at federal and provincial governments. The government of Sindh recently signed a Memorandum of Understanding with German company Azur Solar for building a 50 MW solar power plant at Dhabeji in District Thatta. The firm Azur Solar will initially set up a 60 kW solar power station to provide free electricity to backward 'goths' (Villages), schools and basic health centres of Badin. Both, technical and economical feasibility of a 50 MW solar thermal power plant using Stirling-Dish (SD) technology in Jacaobabad in Sindh Province of Pakistan is analysed in this chapter. The performance and environmental aspects of Stirling dish for power generation with and without solar energy is examined, discussed and compared. The solar data was collected from Bureau of Meteorology (BoM) of Pakistan and Life cycle cost analysis is performed to determine the economic feasibility of the solar thermal power plant. This study reveals that Jacobabad falls within the high solar energy belt and has minimum radiation energy of 4.45 kWh/m2/day (which is higher than the world average of 3.61 kWh/m2/day) to produce electricity, even during the low sunshine and cloudy days. The study concluded that solar thermal power plant in Pakistan is feasible using solar Stirling dish technology

Metasurface-based wideband MIMO antenna for 5G millimeter-wave systems

This paper presents a metasurface based multiple-input multiple-output (MIMO) antenna with a wideband operation for millimeter-wave 5G communication systems. The antenna system consists of four elements placed with a 90 degree shift in order to achieve a compact MIMO system while a 2× 2 non-uniform metasurface (total four elements) is placed at the back of the MIMO configuration to improve the radiation characteristics of it. The overall size of the MIMO antenna is 24× 24 mm2 while the operational bandwidth of the proposed antenna system ranges from 23.5-29.4 GHz. The peak gain achieved by the proposed MIMO antenna is almost 7dB which is further improved up to 10.44 dB by employing a 2× 2 metasurface. The total efficiency is also observed more than 80% across the operating band. Apart from this, the MIMO performance metrics such as envelope correlation coefficient (ECC), diversity gain (DG), and channel capacity loss (CCL) are analyzed which demonstrate good characteristics. All the simulations of the proposed design are carried out in computer simulation technology (CST) software, and measured results reveal good agreement with the simulated one which make it a potential contender for the upcoming 5G communication systems.This work was supported in part by the Universidad Carlos III de Madrid and the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant Agreement No 801538, and in part by the the Ministerio de Ciencia, Innovación y Universidades, Gobierno de España (MCIU/AEI/FEDER,UE) under Grant RTI2018-095499-B-C31

The Response of Pakistan to COVID-19 and Current Situation of Disease in the Country

Background: Coronavirus 2019 (COVID-19) was reported for the first time in China and then quickly spread to other countries. In Pakistan, the first case appeared in Sindh province on February 26, 2020, and within a few weeks, more than 100 cases were reported across the country. Currently, all provinces and territories of the country are affected and cases are growing faster every day. Pakistan is among those countries that have problems with health and diagnostic facilities due to poor economic conditions. Objectives: The present review aims to highlight the emergence, spread and control of the disease in Pakistan. Furthermore, it also highlights the response of Pakistan in the management of COVID-19 outbreak, and the country's contribution in the field of science and technology for the betterment of diagnostic and treatment capabilities against the disease. Methodology: Collection of data was done through national and international forums like Covid-WHO report and COVID-19 Health advisory platform by Ministry of National Health Services Regulation. Results: The important mean for prevention is the proper use of Standard Operating Procedure (SOPs). Quarantine and isolation centers help in limiting the spread of this deadly disease. Conclusion: It is concluded that no vaccine is available for the treatment of this emerging disease so far. The only prevention is to properly and strictly follow the SOPs guidelines

Metasurface-Based Wideband MIMO Antenna for 5G Millimeter-Wave Systems

This paper presents a metasurface based multiple-input multiple-output (MIMO) antenna with a wideband operation for millimeter-wave 5G communication systems. The antenna system consists of four elements placed with a 90 degree shift in order to achieve a compact MIMO system while a 2 x 2 non-uniform metasurface (total four elements) is placed at the back of the MIMO configuration to improve the radiation characteristics of it. The overall size of the MIMO antenna is 24 x 24 mm(2) while the operational bandwidth of the proposed antenna system ranges from 23.5-29.4 GHz. The peak gain achieved by the proposed MIMO antenna is almost 7dB which is further improved up to 10.44 dB by employing a 2 x 2 metasurface. The total efficiency is also observed more than 80% across the operating band. Apart from this, the MIMO performance metrics such as envelope correlation coefficient (ECC), diversity gain (DG), and channel capacity loss (CCL) are analyzed which demonstrate good characteristics. All the simulations of the proposed design are carried out in computer simulation technology (CST) software, and measured results reveal good agreement with the simulated one which make it a potential contender for the upcoming 5G communication systems

Standred interferon therapy and its Response rates in Chronic HCV Patients in District Mardan, Khyber Pakhtunkhwa

To eradicate the Hepatitis C Virus from the bodies of the infected individuals Interferon and Ribavirin based therapy is used. HCV is highly prevalent in District Mardan Khyber Pakhtunkhwa that is why it is important to determine the response of standard interferon based therapy in Chronic HCV patients of this region. A total of 215 patients were selected for interferon based therapy. The patients were selected from three different Tehsil of District Mardan. After confirmation of active HCV infection by q-PCR, standard interferon with Ribavirin was given to patients for 6 months. After completion of therapy, end of treatment virologic response (ETR) was calculated. After completion of the 6 months long therapy, the results obtained were as. Out of total 215 patients, 168 (78.13%) were negative for HCV RNA and showing end of treatment response (ETR) while 47 (21.86%) were positive for HCV RNA and did not show ETR. In Tehsil Mardan, out of 102 patients who had completed therapy, 76 patients (74.51%) showed ETR and 26 (25.49%) did not show the ETR. In Tehsil Kattlang, we found that out of total 51 patients who had taken 6 months therapy, 41 (80.39%) were negative for HCV RNA and 10 (19.61%) were resistant to therapy while in Tehsil Tkhatbhai, out of 62, 50 (80.64%) were negative and 12 (19.35%) were positive. The above discussion shows that antiviral therapy against HCV infection in chronic HCV patients of District Mardan KPK province is 78.13%. The high response rate may be due to the prevalence of genotypes 2 and 3

Design of high gain base station antenna array for mm-wave cellular communication systems

Millimeter wave (mm-Wave) wireless communication systems require high gain antennas to overcome path loss effects and thereby enhance system coverage. This paper presents the design and analysis of an antenna array for high gain performance of future mm-wave 5G communication systems. The proposed antenna is based on planar microstrip technology and fabricated on 0.254 mm thick dielectric substrate (Rogers-5880) having a relative permittivity of 2.2 and loss tangent of 0.0009. The single radiating element used to construct the antenna array is a microstrip patch that has a configuration resembling a two-pronged fork. The single radiator has a realized gain of 7.6 dBi. To achieve the gain required by 5G base stations, a 64-element array antenna design is proposed which has a bore side gain of 21.2 dBi at 37.2 GHz. The 8 × 8, 8 × 16, and 8 × 32 antenna array designs described here were simulated and optimized using CST Microwave Studio, which is a 3D full-wave electromagnetic solver. The overall characteristics of the array in terms of reflection-coefficient and radiation patterns makes the proposed design suitable for mm-Wave 5G and other communication systems.Dr. Mohammad Alibakhshikenari acknowledges support from the CONEX-Plus programme funded by Universidad Carlos III de Madrid and the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No. 801538. In addition, this work was partially supported by Ministerio de Ciencia, Innovación y Universidades, Gobierno de España (Agencia Estatal de Investigación, Fondo Europeo de Desarrollo Regional -FEDER-, European Union) under the research grant PID2021-127409OB-C31 CONDOR. The authors also sincerely appreciate funding from Researchers Supporting Project number (RSP2023R58), King Saud University, Riyadh, Saudi Arabia

Reprogramming tumor-associated macrophages as a unique approach to target tumor immunotherapy

In the last ten years, it has become increasingly clear that tumor-infiltrating myeloid cells drive not just carcinogenesis via cancer-related inflammatory processes, but also tumor development, invasion, and metastasis. Tumor-associated macrophages (TAMs) in particular are the most common kind of leucocyte in many malignancies and play a crucial role in establishing a favorable microenvironment for tumor cells. Tumor-associated macrophage (TAM) is vital as the primary immune cell subset in the tumor microenvironment (TME).In order to proliferate and spread to new locations, tumors need to be able to hide from the immune system by creating an immune-suppressive environment. Because of the existence of pro-tumoral TAMs, conventional therapies like chemotherapy and radiotherapy often fail to restrain cancer growth. These cells are also to blame for the failure of innovative immunotherapies premised on immune-checkpoint suppression. Understanding the series of metabolic changes and functional plasticity experienced by TAMs in the complex TME will help to use TAMs as a target for tumor immunotherapy and develop more effective tumor treatment strategies. This review summarizes the latest research on the TAMs functional status, metabolic changes and focuses on the targeted therapy in solid tumors